Jan Brábek Selected Research

Sarcoma (Soft Tissue Sarcoma)

1/2021	Are We Ready for Migrastatics?
7/2013	Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.
11/2012	NG2-mediated Rho activation promotes amoeboid invasiveness of cancer cells.
9/2008	Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces.

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Jan Brábek Research Topics

Disease

26	Neoplasms (Cancer) 04/2024 - 08/2008
11	Neoplasm Metastasis (Metastasis) 11/2022 - 06/2005
8	Melanoma (Melanoma, Malignant) 01/2024 - 04/2015
4	COVID-19 11/2022 - 06/2020
4	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 09/2008
3	Disease Progression 11/2022 - 06/2021
3	Cytokine Release Syndrome 06/2021 - 06/2020
3	Carcinoma (Carcinomatosis) 04/2021 - 09/2008
2	Inflammation (Inflammations) 02/2022 - 07/2021
2	Virus Diseases (Viral Diseases) 06/2021 - 10/2020
2	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 10/2019
2	Breast Neoplasms (Breast Cancer) 01/2019 - 04/2010
1	Pathologic Processes 11/2022
1	Rheumatoid Arthritis 11/2022
1	Uveal melanoma 07/2021
1	Iron Overload 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Adenocarcinoma of Lung 01/2020
1	Anorexia 02/2019
1	Cachexia 02/2019
1	Fibrosarcoma 01/2018
1	Confusion (Bewilderment) 01/2016

Drug/Important Bio-Agent (IBA)

9	Interleukin-6 (Interleukin 6)IBA 11/2022 - 08/2016
6	Proteins (Proteins, Gene)FDA Link 07/2021 - 08/2008
5	CytokinesIBA 11/2022 - 08/2016
5	CollagenIBA 07/2021 - 01/2018
3	Interleukin-8 (Interleukin 8)IBA 02/2022 - 08/2016
2	AntibodiesIBA 01/2024 - 08/2016
2	Cytostatic AgentsIBA 01/2021 - 01/2017
2	Peptide Hydrolases (Proteases)FDA Link 07/2013 - 09/2008
1	AntigensIBA 01/2024
1	Monoclonal AntibodiesIBA 11/2022
1	SaltsIBA 10/2022
1	ChemokinesIBA 02/2022
1	Interleukin-2 (IL2)IBA 07/2021
1	Biomarkers (Surrogate Marker)IBA 07/2021
1	Interferon-gamma (Interferon, gamma)IBA 07/2021
1	Estrogens (Estrogen)FDA Link 06/2021
1	Estrogen Receptor Modulators (Antiestrogen)IBA 06/2021
1	Estrogen ReceptorsIBA 06/2021
1	Chelating AgentsIBA 01/2021
1	Deferoxamine (Desferal)FDA LinkGeneric 01/2021
1	Heme (Haem)IBA 01/2021
1	IronIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	p38 Mitogen-Activated Protein KinasesIBA 01/2021
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 10/2020
1	protein kinase NIBA 10/2020
1	Interferon Type IIBA 08/2020
1	InterferonsIBA 08/2020
1	Antiparasitic Agents (Antiparasitics)IBA 05/2020
1	VimentinIBA 01/2020
1	Long Noncoding RNAIBA 01/2020
1	AndrogensIBA 10/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2019
1	src-Family KinasesIBA 01/2019
1	GelsIBA 05/2018
1	Conditioned Culture MediaIBA 08/2016
1	matrigelIBA 04/2015
1	Guanosine Triphosphate (GTP)IBA 11/2012
1	Chondroitin Sulfate ProteoglycansIBA 11/2012
1	LigandsIBA 11/2011
1	EnzymesIBA 09/2010
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 04/2010
1	GelatinIBA 04/2010
1	Protease Inhibitors (Protease Inhibitor)IBA 09/2008
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2008
1	Tyrosine (L-Tyrosine)FDA Link 06/2005
1	Crk-Associated Substrate ProteinIBA 06/2005

Therapy/Procedure

8	Therapeutics 04/2024 - 01/2016
2	Castration 01/2021 - 10/2019
1	Precision Medicine 01/2016